# Ionis Shares Fall About 27% After Tryngolza Sales Forecast Cut By John Kim Canonical URL: https://www.tokenpost.com/news/business/53184 Published: 2026-11-10T15:39:57.000Z Updated: 2026-11-10T15:39:57.000Z Section: Business > Ionis lowered its 2026 sales outlook for the drug to about $50 million from $100 million to $110 million, despite third-quarter results that beat expectations. Ionis Pharmaceuticals shares fell about 27% Monday after the company cut its 2026 sales forecast for Tryngolza, outweighing third-quarter results that exceeded revenue and earnings expectations. Ionis now expects about $50 million in 2026 sales of Tryngolza (olezarsen), down from its previous forecast of $100 million to $110 million. The new target is about half the bottom of the earlier range. Tryngolza is a treatment for severe hypertriglyceridemia. The forecast cut accompanied third-quarter results that beat expectations for both revenue and earnings. For the quarter ended Sept. 30, Ionis [recorded $243 million in revenue and a $0.66 per-share loss]() under generally accepted accounting principles. The revised outlook covers sales of Tryngolza for the full year. The $243 million revenue figure covers Ionis as a whole for the third quarter. ## Links in this article - [recorded $243 million in revenue and a $0.66 per-share loss](https://www.tokenpost.com/news/business/52882)