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Acumen Shares Fall More Than 80% After Alzheimer’s Trial Miss

The midstage ALTITUDE-AD study tested sabirnetug. Acumen had $78.6 million in cash, cash equivalents and marketable securities as of Sept. 30.

An unmarked vial sits beside an empty clinical research chair / TokenPost.ai
An unmarked vial sits beside an empty clinical research chair / TokenPost.ai

Acumen Pharmaceuticals (NASDAQ: ABOS) shares fell more than 80% in premarket trading Friday, Oct. 30, after the company announced its midstage Alzheimer’s trial missed primary and key secondary endpoints for its lead candidate, sabirnetug.

The ALTITUDE-AD study tested sabirnetug in patients with Alzheimer’s disease. Acumen’s third-quarter results put its cash, cash equivalents and marketable securities at $78.6 million as of Sept. 30. The company expected that balance to support clinical and operating activities into early 2027.

John Kim

John Kim reports on the digital-asset business for TokenPost. Send corrections or tips to info@tokenpost.com.

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